Forscherin arbeitet mit Reagenzglas
[Translate to English:] Sieben ausgewählte Forschungsprojekte treiben Ersatzmethoden für Tierversuche voran. © Unsplash/Julia Koblitz

The Austrian Science Fund (FWF) has approved seven projects in the third round of the Alternative Methods to Animal Testing funding program. The findings of the new research projects will help find methods to replace animal experiments in research, further reduce their use, or minimize animal suffering. 

A total of 31 researchers from seven different research institutions submitted proposals, with a total application volume of €11.6 million. The FWF approved seven of these applications for funding, with a total volume of around €2.7 million. Projects were chosen for their excellent scientific quality on the basis of an international review.

Fourth call for applications starts in February 2024

The funding program is open to researchers from all disciplines and funds projects that make a significant contribution to the discovery and development of alternative methods. The program is based on the 3Rs principle described by Russel and Burch: The aim is to develop research and testing methods that completely replace animal testing (replacement), reduce the number of animals used (reduction), or minimize the animals’ pain and distress (refinement).

The program is funded by the Federal Ministry of Education, Science and Research (BMBWF). Funding for projects that exceed the BMBWF budget is provided by the FWF. The fourth call for applications for the program will open on February 12 and run until May 13, 2024.

The new research projects at a glance

Here you can find an overview of the seven new approvals – the first two projects are funded directly by the Federal Ministry of Education, Science and Research (BMBWF), the other five by the FWF.

Dog on a Chip

The aim of the project is to create a versatile organoid-on-a-chip platform for dogs that replaces animal testing. The focus is on the gastrointestinal tract and related organs.

 

Principal investigator

Iwan Burgener

Research institution

University of Veterinary Medicine, Vienna

Funding volume

€398,958

HIPSC-LCH

The overall aim of this project is to develop an in vitro system for Langerhans cell histiocytosis (LCH). Patient-derived induced pluripotent stem cells (iPSCs) are used as the basis for the research.

 

Principal investigator

Caroline Hutter

Research institution

St. Anna Children’s Cancer Research Institute

Funding volume

€399,010

Assessment of Cartilage Graft Maturation in Vitro

The project aims to develop novel strategies for the screening and identification of cartilage grafts produced in vitro. Metabolic changes could serve as an additional marker for the identification of in vivo-ready cartilage grafts.

 

Principal investigator

Cornelia Kasper

Research institution

University of Natural Resources and Life Sciences, Vienna

Funding volume

€382,624

InSilify DrugTox

The overarching research question behind this study is whether available QSAR models reliably predict drug toxicity. A comprehensive data set from drug development and use will be curated for this purpose.

 

Principal investigator

Martin Walter

Research institution

Austrian Agency for Health and Food Safety (AGES)

Funding volume

€365,270

DIGI-SKIN: Open-Access scRNA-Seq Mouse Skin Atlas

To reduce the use of mice in research and enable the study of  complex biological tissues such as skin, this project aims to provide the largest and most versatile digital cell atlas of mouse skin available online.

 

Principal investigator

Mikolaj Bogdan Ogrodnik

Research institution

Ludwig Boltzmann Gesellschaft; Medical University of Vienna

Funding volume

€392,012

The Biomechanical Synovium

The project aims to introduce physiological biomechanical activation as an important control parameter to reduce or replace the number and need for rodent models of rheumatoid arthritis.

 

Principal investigator

Mario Rothbauer

Research institution

Medical University of Vienna

Funding volume

€398,029

Replace Mice Xenografts by MIcrofluidic CancerogEnesis Chips

The project is working on a human in-vitro model on a bioelectronic sensor chip to replace animal testing. Only animal-free materials are used.

 

Principal investigator

Heinz Wanzenböck

Research institution

TU Wien; Medical University of Graz

Funding volume

€399,998

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