ERA-NET: Permed
Disciplines
Clinical Medicine (40%); Medical-Theoretical Sciences, Pharmacy (60%)
Keywords
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Personalized Medicine,
Depression,
Biomarkers,
Functional Imaging,
Machine Learning
Personalised medicine aims to predict therapeutic response according to a personal profile that includes clinical, biological, and genetic data. This project focuses on depression. It aims to establish an artificial intelligence platform that brings together data from clinical research on the components of these profiles with the purpose of identifying predictors for response to depression treatment. The results will be combined into a single data platform that enables the use of large multimodal datasets to develop predictive models of symptoms and outcome data, thus enhancing the impact of these data. Artificial intelligence approaches will be investigated to identify novel biomarkers that can predict response to treatment. This will help to develop of a decision support system for personalised therapy while identifying the specific ethical and legal requirements that need to be fulfilled.
- Universität Innsbruck - 100%
- Nada Bozina, Universität Zagreb - Croatia
- Catharina Scholl, Sonstige Forschungs- oder Entwicklungseinrichtungen - Germany
- Noam Shomron, Tel-Aviv University - Israel
- Maria Giulia Bacalini, University of Bologna - Italy
- Espen Molden, University of Oslo - Norway
Research Output
- 15 Citations
- 8 Publications
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2025
Title Pharmacogenetic guided drug therapy – how to deal with phenoconversion in polypharmacy DOI 10.1080/17425255.2025.2451440 Type Journal Article Author Stingl J Journal Expert Opinion on Drug Metabolism & Toxicology Pages 1-9 Link Publication -
2024
Title Phenotypic Models of Drug–Drug-Gene Interactions Mediated by Cytochrome Drug-Metabolizing Enzymes DOI 10.1002/cpt.3188 Type Journal Article Author Viviani R Journal Clinical Pharmacology & Therapeutics Pages 592-601 Link Publication -
2024
Title The fMRI global signal and its association with the signal from cranial bone DOI 10.1101/2024.03.27.587003 Type Preprint Author Huber D Pages 2024.03.27.587003 Link Publication -
2024
Title Cognitive effort and reward. Functional imaging of time on task and the involvement of dopaminergic and cholinergic substrates DOI 10.1101/2024.12.12.628171 Type Preprint Author Orsini C Pages 2024.12.12.628171 Link Publication -
2024
Title The fMRI global signal and its association with the signal from cranial bone DOI 10.1016/j.neuroimage.2024.120754 Type Journal Article Author Huber D Journal NeuroImage Pages 120754 Link Publication -
2024
Title The dark side of personality functioning: associations between antisocial cognitions, personality functioning (AMPD), empathy and mentalisation DOI 10.3389/fpsyt.2024.1377177 Type Journal Article Author Rabl L Journal Frontiers in Psychiatry Pages 1377177 Link Publication -
2023
Title Phenotypic models of drug-drug-gene interactions mediated by cytochrome drug-metabolizing enzymes DOI 10.1101/2023.11.02.23297749 Type Preprint Author Viviani R Pages 2023.11.02.23297749 Link Publication -
2022
Title Pharmacogenetic Dose Modeling Based on CYP2C19 Allelic Phenotypes DOI 10.3390/pharmaceutics14122833 Type Journal Article Author Stingl J Journal Pharmaceutics Pages 2833 Link Publication