Disciplines
Medical-Theoretical Sciences, Pharmacy (100%)
Keywords
Reporter mouse model,
Conditional Knockout Mouse Models,
Immune Cell Differentiation,
Bone Marrow Microenvironment,
Mesenchymal Stromal Cell Subsets,
Single-Cell Rna Sequencing
Abstract
The bone marrow is responsible for blood formation and the maturation of immune system
cells. The supporting cells of the bone marrow, so-called stromal cells, play an important role
in these processes. However, stromal cells also have tissue regenerative and immune-
regulating properties, which is why stromal cells are of interest for numerous clinical
applications. In this research project, we investigate which types of stromal cells are
responsible for the many different functions. This should shed light on which types of stromal
cells are best suited for different clinical applications. Using the latest sequencing and analysis
technologies, our interdisciplinary research team will create a detailed functional map of
stromal cells in mice and humans. The findings from this basic research project may also be
relevant for cancer research, as different types of stromal cells also occur in the tumor and
strongly influence the immune cells and the formation of metastases.