MUW International PhD Program in Translational Oncology (IPPTO)
MUW International PhD Program in Translational Oncology (IPPTO)
Disciplines
Clinical Medicine (25%); Medical-Theoretical Sciences, Pharmacy (75%)
Keywords
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Novel Cancer Therapies,
Cancer Immunotherapy,
Therapy Resistance,
Mouse Models,
Cancer Immunology,
Non-Genetic Cancer Cell Plasticity
The unprecedented understanding of the molecular underpinning of cancer has led to an explosion of targeted therapy options that are developed at a rapid pace. Cancer immunotherapy, genome editing and rational drug design are just a few of the novel ideas that will massively change how we target cancer therapeutically. However, there are numerous challenges that need to be overcome before delivering on the promise of personalized cancer therapy. Clinical evidence shows that, despite initial response to treatment, most tumors become resistant to eventually all available therapy by alterations of the malignant cells or the tumor microenvironment. In recognition of this challenge, we propose to establish a new research focus dedicated to mechanisms shaping anticancer therapy response. With a significant in-kind contribution from the Medical University of Vienna (MUW) matching the FWF DOC funds, our aim is to improve the already existing and highly successful Malignant Diseases doctoral program (MADI), which is one of the largest and best-established thematic PhD programs of the MUW. The novel International PhD Program in Translational Oncology (IPPTO) is a closed excellence program run by 14 MUW scientists of the MADI faculty with a wide range of expertise and research interests. One-third of the faculty members are women, including a highly successful female young group leader, reflecting our vision to support and embrace early-career scientists who have the potential to serve as academic role models in research and education. The proposed IPPTO projects belong to three research areas, focusing on cellular resistance mechanisms, tumor plasticity and the tumor microenvironment. The success of this three- pronged approach is hinged on the excellence and commitment of the faculty members to train future scientists through innovative and exciting research. Students will benefit from the thematic coherence of the projects, the collaboration network of the faculty members, the interdisciplinary approach, the shared resources and a team-level supervision. The program will include customized training courses, seminars and regular participation in national and international meetings. Our long-term goal is to create an internationally visible excellence program in translational oncology. An increase of the quality of graduate training and career development in oncology will strengthen the research cluster Cancer Research and Oncology at MUW and the entire Austrian cancer research potential to promote the translation of basic scientific discoveries into clinical benefit for cancer patients.
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
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consortium member (1.10.2019 - 30.9.2024)
- Medizinische Universität Wien
Research Output
- 243 Citations
- 40 Publications
- 1 Fundings
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2024
Title Human monocyte subsets differ in their capacity to form extracellular traps DOI 10.1038/s41420-024-02034-y Type Journal Article Author Ibrahim N Journal Cell Death Discovery Pages 281 Link Publication -
2024
Title Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands DOI 10.1021/acs.jmedchem.3c01036 Type Journal Article Author Teixeira R Journal Journal of Medicinal Chemistry Pages 6081-6098 Link Publication -
2024
Title Reducing Abdominal Aortic Aneurysm Progression by Blocking Neutrophil Extracellular Traps Depends on Thrombus Formation DOI 10.1016/j.jacbts.2023.11.003 Type Journal Article Author Ibrahim N Journal JACC: Basic to Translational Science Pages 342-360 Link Publication -
2024
Title Differential regulation of human thrombospondin-1 upon systemic desmopressin versus endotoxin challenge DOI 10.1016/j.thromres.2024.01.011 Type Journal Article Author Scheuba A Journal Thrombosis Research Pages 205-208 Link Publication -
2024
Title A novel function of STAT3ß in suppressing interferon response improves outcome in acute myeloid leukemia DOI 10.1038/s41419-024-06749-9 Type Journal Article Author Edtmayer S Journal Cell Death & Disease Pages 369 Link Publication -
2024
Title The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition DOI 10.7554/elife.96850.1 Type Preprint Author Kavaklıoğlu G -
2024
Title 15 years Ludwig Boltzmann Institute for Hematology and Oncology (LBI HO): achievements and future perspectives DOI 10.1007/s12254-024-00966-w Type Journal Article Author Hadzijusufovic E Journal memo - Magazine of European Medical Oncology -
2024
Title A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine DOI 10.1007/s13402-024-00960-8 Type Journal Article Author Kalla J Journal Cellular Oncology Pages 1-26 Link Publication -
2024
Title Tumor-Extrinsic Axl Expression Shapes an Inflammatory Microenvironment Independent of Tumor Cell Promoting Axl Signaling in Hepatocellular Carcinoma DOI 10.3390/ijms25084202 Type Journal Article Author Breitenecker K Journal International Journal of Molecular Sciences Pages 4202 Link Publication -
2023
Title PRAME Is a Novel Target of Tumor-Intrinsic Gas6/Axl Activation and Promotes Cancer Cell Invasion in Hepatocellular Carcinoma DOI 10.3390/cancers15092415 Type Journal Article Author Hedrich V Journal Cancers Pages 2415 Link Publication -
2023
Title Modeling the Tumor Microenvironment and Cancer Immunotherapy in Next-Generation Humanized Mice DOI 10.3390/cancers15112989 Type Journal Article Author Chen A Journal Cancers Pages 2989 Link Publication -
2023
Title Mimicking Tumor Cell Heterogeneity of Colorectal Cancer in a Patient-derived Organoid-Fibroblast Model DOI 10.1016/j.jcmgh.2023.02.014 Type Journal Article Author Atanasova V Journal Cellular and Molecular Gastroenterology and Hepatology Pages 1391-1419 Link Publication -
2023
Title Engraftment in NSGSCF mice correlates with the WHO category and prognosis in systemic mastocytosis DOI 10.1038/s41375-023-01871-7 Type Journal Article Author Willmann M Journal Leukemia Pages 1162-1165 Link Publication -
2023
Title Phenotypic characterization of disease-initiating stem cells in JAK2- or CALR-mutated myeloproliferative neoplasms DOI 10.1002/ajh.26889 Type Journal Article Author Ivanov D Journal American Journal of Hematology Pages 770-783 Link Publication -
2023
Title Antibody-Based and Cell Therapies for Advanced Mastocytosis: Established and Novel Concepts DOI 10.3390/ijms242015125 Type Journal Article Author Valent P Journal International Journal of Molecular Sciences Pages 15125 Link Publication -
2023
Title Targeting YB-1 via entinostat enhances cisplatin sensitivity of pleural mesothelioma in vitro and in vivo DOI 10.1016/j.canlet.2023.216395 Type Journal Article Author Schelch K Journal Cancer Letters Pages 216395 Link Publication -
2023
Title Carboplatin-induced upregulation of pan ß-tubulin and class III ß-tubulin is implicated in acquired resistance and cross-resistance of ovarian cancer DOI 10.1007/s00018-023-04943-0 Type Journal Article Author Pernar Kovac M Journal Cellular and Molecular Life Sciences Pages 294 Link Publication -
2023
Title Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma DOI 10.3389/fonc.2023.1238883 Type Journal Article Author Breitenecker K Journal Frontiers in Oncology Pages 1238883 Link Publication -
2023
Title Defects in microvillus crosslinking sensitize to colitis and inflammatory bowel disease DOI 10.15252/embr.202357084 Type Journal Article Author Mödl B Journal EMBO reports Link Publication -
2023
Title Quantitation of oxidized nuclear and mitochondrial DNA in plasma samples of patients with abdominal aortic aneurysm DOI 10.1016/j.freeradbiomed.2023.06.014 Type Journal Article Author Hayden H Journal Free Radical Biology and Medicine Pages 94-105 Link Publication -
2023
Title Gas6 in chronic liver disease—a novel blood-based biomarker for liver fibrosis DOI 10.1038/s41420-023-01551-6 Type Journal Article Author Staufer K Journal Cell Death Discovery Pages 282 Link Publication -
2023
Title STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway DOI 10.1186/s12943-023-01825-8 Type Journal Article Author Pencik J Journal Molecular Cancer Pages 133 Link Publication -
2023
Title Vienna Cancer Stem Cell Club (VCSCC): 20 year jubilee and future perspectives DOI 10.1080/17474086.2023.2232545 Type Journal Article Author Valent P Journal Expert Review of Hematology Pages 659-670 -
2023
Title Characerization and standardized analysis of B cell and TLS phenotypes during human melanoma progression Type PhD Thesis Author Franziska Werner -
2022
Title PD-L1 overexpression correlates with JAK2-V617F mutational burden and is associated with 9p uniparental disomy in myeloproliferative neoplasms DOI 10.1002/ajh.26461 Type Journal Article Author Feenstra J Journal American Journal of Hematology Pages 390-400 Link Publication -
2022
Title Identification of CD203c as a New Basophil-Specific Flow-Marker in Ph+ Chronic Myeloid Leukemia DOI 10.3390/cells12010003 Type Journal Article Author Sadovnik I Journal Cells Pages 3 Link Publication -
2020
Title Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux DOI 10.1021/acs.jmedchem.0c01277 Type Journal Article Author Nunes J Journal Journal of Medicinal Chemistry Pages 13719-13732 Link Publication -
2022
Title Tyk2 is a tumor suppressor in colorectal cancer DOI 10.1080/2162402x.2022.2127271 Type Journal Article Author Moritsch S Journal OncoImmunology Pages 2127271 Link Publication -
2022
Title Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance DOI 10.3390/cancers14184455 Type Journal Article Author Pósa V Journal Cancers Pages 4455 Link Publication -
2022
Title The intermicrovillar adhesion complex in gut barrier function and inflammation DOI 10.37349/edd.2022.00006 Type Journal Article Author Mödl B Journal Exploration of Digestive Diseases Pages 72-79 Link Publication -
2022
Title 3D Ultrasound Measurements Are Highly Sensitive to Monitor Formation and Progression of Abdominal Aortic Aneurysms in Mouse Models DOI 10.3389/fcvm.2022.944180 Type Journal Article Author Ibrahim N Journal Frontiers in Cardiovascular Medicine Pages 944180 Link Publication -
2022
Title Discovery of the cyclotide caripe 11 as a ligand of the cholecystokinin-2 receptor DOI 10.1038/s41598-022-13142-z Type Journal Article Author Taghizadeh M Journal Scientific Reports Pages 9215 Link Publication -
2022
Title Type I and II interferon signaling in colorectal cancer liver metastasis DOI 10.1016/j.cyto.2022.156075 Type Journal Article Author Mödl B Journal Cytokine Pages 156075 Link Publication -
2020
Title STAT5 is Expressed in CD34+/CD38- Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms DOI 10.3390/cancers12041021 Type Journal Article Author Hadzijusufovic E Journal Cancers Pages 1021 Link Publication -
2020
Title Cell-based and antibody-mediated immunotherapies directed against leukemic stem cells in acute myeloid leukemia: Perspectives and open issues DOI 10.1002/sctm.20-0147 Type Journal Article Author Valent P Journal STEM CELLS Translational Medicine Pages 1331-1343 Link Publication -
2020
Title The Implications of PDK1-4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance. DOI 10.3389/fonc.2020.583217 Type Journal Article Author Atas E Journal Frontiers in oncology Pages 583217 -
2021
Title Loss of Lymphotoxin Alpha-Expressing Memory B Cells Correlates with Metastasis of Human Primary Melanoma DOI 10.3390/diagnostics11071238 Type Journal Article Author Werner F Journal Diagnostics Pages 1238 Link Publication -
2021
Title Down-regulation of A20 promotes immune escape of lung adenocarcinomas DOI 10.1126/scitranslmed.abc3911 Type Journal Article Author Breitenecker K Journal Science Translational Medicine Link Publication -
2021
Title Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms DOI 10.1016/j.trsl.2021.02.003 Type Journal Article Author Eilenberg W Journal Translational Research Pages 32-46 Link Publication -
2021
Title Phenotypic characterization of leukemia-initiating stem cells in chronic myelomonocytic leukemia DOI 10.1038/s41375-021-01227-z Type Journal Article Author Eisenwort G Journal Leukemia Pages 3176-3187 Link Publication
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2024
Title Functional heterogeneity of mesenchymal stromal cells Type Research grant (including intramural programme) Start of Funding 2024 Funder Austrian Science Fund (FWF)