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Job-Art: Wissenschaftliche Jobausschreibungen

Technical Assistant (75 %)

Molecular Biology ("Immunocytoskeleton")
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases


The Dupré Group at LBI-RUD, the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases in Vienna, seeks to fill the open part-time (75%) position of a


LBI-RUD, a young and innovative institute pursuing basic and translational research on rare genetic diseases, is looking for a highly motivated technical assistant to take part in an exciting project within the “immunocytoskeleton” group of Dr. Loïc Dupré.

The group focus:

Our group focuses on deciphering how immune cells remodel their actin cytoskeleton to migrate, interact with other cells, and execute their function. Our long-term goal is to identify the molecular network that sustains actin cytoskeleton dynamics upon the many steps of immune cell life cycle. Using rare congenital immunodeficiencies as natural models of cytoskeleton defects and combination of high-resolution and high-content microscopy methods we attempt to characterize structural, morphological and functional impairments in patient-derived primary cells.

Key publications:

- Houmadi R et al. The Wiskott-Aldrich Syndrome Protein contributes to the assembly of the LFA-1 nanocluster belt at the lytic synapse. Cell Reports, 2018,22:979-991.

- Pfajfer L et al. Mutations affecting the actin regulator WDR1 lead to aberrant lymphoid immunity. J Allergy Clin Immunol, 2018,142:1589-1604.

The position:

The group is looking for a highly motivated and well-organized technical assistant, who will

be fully integrated into the scientific projects. This position is ideally suited for individuals

who seek to participate in every aspect of laboratory activities, such as data analysis, wet

bench research, budgeting and lab management. As a career-building benefit, the successful

applicant will receive the necessary training to independently design, conduct and

interpret experiments.

Tasks and responsibilities include:

  • Human blood processing (PBMC isolation & purification of immune cell subsets)
  • Establishment and propagation of primary human cells lines
  • Flow cytometry & fluorescence-activated cell sorting (FACS)
  • Immunofluorescent and live-cell microscopy
  • Biochemistry (SDS-PAGE Western blotting)
  • Molecular biology techniques (PCR, cloning, CRISPR/Cas9, viral preparations)
  • Data analysis (including statistical analysis and visualization of quantitative data)
  • Documentation, interpretation and reporting of experiments and results
  • Contribution to lab management (ordering, preparation of general reagents and budgeting)

Requirements and desired qualifications:

  • Bachelor degree in Life Sciences or a TA/MTA diploma, Master degree is considered a plus
  • Wet lab experience in molecular or cell biology techniques
  • Fluency in English, proficiency in German is an asset

We offer:

  • a challenging position in a meaningful, inspiring, productive, friendly and international setting
  • training in various techniques, opportunity to attend meetings, seminars, symposia, and workshops as well as opportunity to present your own work at various venues.
  • an excellent work climate and the possibility to join our social (cultural or sports) activities
  • a part-time employment (75%) contract with a competitive salary (remunerated according to FWF personnel costs (http://www.fwf.ac.at/en/research-funding/personnel-costs) depending on the education and qualifications of the successful applicant.

The Institute:

Our group is part of the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD) and is located within the Dermatology Department of the Vienna General Hospital (Allgemeines Krankenhaus der Stadt Wien), one of Europe’s largest university hospitals in the heart of the city. We have access to state-of-the art technology platforms, close collaborations with geneticists and clinicians, as well as basic researchers, particularly in our renowned partner institutions, namely the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, the Medical University of Vienna (MedUni Vienna), and the St. Anna Children’s Cancer Research Institute (CCRI).

For more information visit: www.rare-diseases.at

We are committed to creating a diverse environment. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, and age.

How to apply?

Please send your CV and additional application materiel to application(at)rud.lbg.ac.at. Your application should consist of the following documents:

  • CV
  • Motivation letter (describing your career goals and explaining why you are the ideal candidate for this position)
  • Relevant degrees and certificates
  • Names and contact of 2 references
  • Optional: publication list

Deadline for the application is Friday, January 31, 5 pm (GMT +1)


Name: Maximilian Rau
Telefon: +4314016070093

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