PhD Position in Cancer Research
- Cancer Immunology
- Institute of Cancer Research
The research team of Robert Eferl at the Medical University Vienna is looking for a motivated PhD student that is interested to investigate immune escape mechanisms of colorectal cancer.
The Janus Kinase TYK2 plays an important role in autoimmunity but its role in formation of colorectal cancer is unclear. Our data suggest that TYK2 enhances the immunogenicity of colorectal tumors, which sensitizes them to immunotherapies. Identification of the underlying molecular mechanisms is the focus of this PhD project.
Our research group uses genetic and chemical colorectal cancer mouse models to study the importance of cytokine signaling in tumor progression. Using wet-lab and OMIC techniques, we identified pivotal functions of JAK-STAT signaling components in tumor cells and tumor-associated macrophages of colorectal cancer (e.g. Crncec et al, Molecular Oncology 2018, Pathria et al, OncoImmunology 2015, Musteanu et al, Gastroenterology 2010). Our research team is manageable but well embedded in the scientific community of the Institute of Cancer Research at the Medical University Vienna (http://krebsforschung.meduniwien.ac.at).
The PhD candidate should be a motivated researcher with a master’s degree and experience in cancer research, molecular biology or immunology. He/She should be self-driven and own excellent organizational skills. Written and oral communication in English is a precondition for a successful application. The expected starting date is March 2020.
Please submit a letter of motivation, a Curriculum Vitae, a publication list and preferably two reference letters to Robert Eferl (robert.eferl(at)meduniwien.ac.at).
- Name: Robert Eferl
- Telefon: 0043 1 40160 57571