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Job-Art: Wissenschaftliche Jobausschreibungen

PhD student position in Gene regulation in Kidney Disease

Fachgebiet
Epigenetics
Arbeitsstätte
University of Veterinary Medicine
Website
Bewerbungsfrist
07.01.2019
science4refugee

Ausschreibungstext

The Department of Biomedical Research, Unit of Physiology, Pathophysiology and Experimental Endocrinology at the University of Veterinary Medicine, Vienna invites applicants for a

 

PhD student position in Gene regulation in Kidney Disease

 

Research scope:

The project focuses on enhancer and super-enhancer regulation in kidney disease. The overall aim is to understand the transcriptional regulation of kidney specific programs in normal homeostasis and in kidney disease with focus on enhancer hierarchies, transcription factor identification / cooperation and in vivo validation with CRISPR/Cas9 gene or base editing tools. Specifically, we will build upon the technologies that we have already implemented/applied, such as RNA-seq, ChIP-seq, Hi-C and CRISPR/Cas9 mice. We believe our comprehensive analysis of epigenetic changes after kidney injury in vivo provides a detailed molecular model and rich resource, and has the potential to identify new targets for therapeutic intervention.

 

Research project:

The project is designed to enhance the laboratory skills and facilitate the professional development of the student in a translational medicine research project. We are seeking a PhD student to study the enhancer and super-enhancer dynamics after kidney injury and repair whereby the focus will be (1) to characterize the enhancer landscape in the kidney, (2) to validate/dissect enhancer function of selected genes (e.g., Klotho), and (3) to study the pathophysiological consequences of disturbed enhancer regulation in vivo. This project will primarily involve small animal surgery and CRISPR/Cas9 base editing mouse model, and will require experience with NGS (RNA-seq and ChIP-seq), histology, immunohistochemistry, and standard molecular biology techniques for DNA, RNA, and protein analysis.

 

We seek:

We expect applications from highly motivated graduate students in medicine, veterinary medicine, biology, genetics or pharmacy with an excellent academic background. Applicants are required to have graduated above average at a Master level or equivalent by the time of their application. He or she should have a background in molecular biology with experimental experience and the willingness to also work with mice. The applicant must be fluent in English (level B2 or higher).

 

We offer:

Starting as soon as possible, we offer a 3-year position for a PhD student in an internationally embedded and fully funded project under the supervision of Dr. Julia Wilflingseder and Prof. Dr. Reinhold Erben with international cooperation partners at NIH, NIDDK (Dr. Lothar Hennighausen) and Brigham and Women’s Hospital, Harvard Medical School (Dr. Joseph V. Bonventre). Research stays abroad in the laboratories of our collaboration partners are planned and appreciated. Besides the experimental work towards the PhD degree the doctorate program involves a structured training and mentoring program with journal clubs, progress reports and regular lectures. Salaries will be according to the Austrian collective labor agreement.

 

The deadline for receipt of applications is Jan. 07, 2019. Please send your application including CV, scientific experience, and references to bewerbungen(at)vetmeduni.ac.at, mentioning the code number 2018/1122.

 

 

Kontakt-Person(en)

Haupt-Kontakt
Name: Dr. Julia Wilflingseder

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